In plants, resveratrol acts as a phytoalexin that is synthesized in response to mechanical injury, UV irradiation and fungal attacks. High concentrations are present in grapes, possibly because of Vitis vinifera response to fungal infection. This natural polyphenol has been detected in more than 70 plant species, and is also found in discrete amounts in red wines and various human foods. Loes) roots in 1940, then from Polygonum cuspidatum roots in 1963, a plant used in traditional Chinese and Japanese Medicine as anti-inflammatory and anti-platelet agent. Resveratrol was first isolated from white hellebore ( Veratrum grandiflorum O. Resveratrol has since received an increasing scientific attention, leading to investigation on its biological activity, and to numerous publications. Renaud and De Lorgeril were the first to relate wine polyphenols such as resveratrol, to the potential health benefits attributed to regular and moderate wine consumption (the so called “French Paradox”). Specifically, resveratrol is well known biologically active compound synthesized by plants undergoing infectious or ionizing radiation. From them, stilbenes, in particular trans-resveratrol and its glucoside, are widely reported to be beneficial to human health, having even shown to possess antioxidant, anticarcinogenic, antitumor and estrogenic/antiestrogenic activity. These compounds can be classified into four main groups, such as isoflavonoids, flavonoids, stilbenes and lignans. In this sense, this review summarized current data on resveratrol pharmacological effects.Īmong many phytochemicals, phytoestrogens have been reported to contain several bioactive molecules, mostly found in soy, vegetables and fruits. Nonetheless, resveratrol application is still being a major challenge for pharmaceutical industry, due to its poor solubility and bioavailability, as well as adverse effects. Even more, other bioactive effects, namely as anti-inflammatory, anticarcinogenic, cardioprotective, vasorelaxant, phytoestrogenic and neuroprotective have also been reported. Indeed, resveratrol anticancer properties have been confirmed by many in vitro and in vivo studies, which shows that resveratrol is able to inhibit all carcinogenesis stages (e.g., initiation, promotion and progression). Resveratrol also exhibit antitumor activity, and is considered a potential candidate for prevention and treatment of several types of cancer. As a natural food ingredient, numerous studies have demonstrated that resveratrol possesses a very high antioxidant potential. It is a phytoalexin that acts against pathogens, including bacteria and fungi.
WOOD KATANA LONG SKIN
This natural polyphenol has been detected in more than 70 plant species, especially in grapes’ skin and seeds, and was found in discrete amounts in red wines and various human foods. Resveratrol (3,5,4′-trihydroxy-trans-stilbene) belongs to polyphenols’ stilbenoids group, possessing two phenol rings linked to each other by an ethylene bridge.
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